STUDIES ON THE MACROLIDE ANTIBIOTIC YL-704 COMPLEX. II
نویسندگان
چکیده
منابع مشابه
The structure of vacidin A, an aromatic heptaene macrolide antibiotic. II. Stereochemistry of the antibiotic.
On the basis of coupling constants and rotating frame nuclear Overhauser effect spectroscopy of vacidin A methoxycarbonylmethylamide, the stereochemistry of the antibiotic was established. The configuration of the aglycone was determined as (3R,7R,9R,11S,13S,15R,17S,18R,19S,21R, 36S,37R,38S). The aminosugar constituent of the antibiotic was identified as beta-(D)-mycosamine. The chiral center a...
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A new antibiotic swalpamycin (1) has been isolated from the culture broth of Streptomyces sp. Y-84,30967. The antibiotic has the molecular formula of C37H56O14 and belongs to the class of 16-membered neutral macrolide antibiotics. Its structure has been elucidated by an analysis of its spectral properties. It contains a novel aglycone herein called swalpanolide.
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Structure of a novel antibiotic, sporeamicin A (SRM-A), was determined by a combination of spectroscopic and X-ray crystallographic studies. SRM-A has a unique structure containing a 2,3-dihydro-3-oxofuran moiety as part of a 14-membered macrolide ring.
متن کاملPart 452—macrolide Antibiotic Drugs
(ii) Samples required: (a) The mitomycin used in making the batch: Five packages, each containing approximately 100 milligrams. (b) The batch: (1) For all tests except sterility: A minimum of 25 immediate containers. (2) For sterility testing: 20 immediate containers, collected at regular intervals throughout each filling operation. (b) Tests and methods of assay—(1) Potency. Proceed as directe...
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A convergent asymmetric synthesis of the antineoplastic macrolide antibiotic cytovaricin has been achieved through the synthesis and coupling of the illustrated spiroketal and polyol glycoside subunits. All absolute stereochemical relationships within the target structure were ultimately controlled by the use of asymmetric aldol, alkylation, or epxidation methodology. Union of the two subunits ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1974
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.27.102